Though the U.S. has seen tremendous progress in the fight against COVID-19, there are still causes for concern in the rare disease community. Emerging data shows COVID-19 vaccines may be less effective for people with some immune compromising conditions. Patients and caregivers with questions about the COVID-19 vaccine, new mask guidance or other best practices to stay safe, are urged to talk to their health care team, particularly if they have received a solid-organ transplant, have immunocompromising conditions, or are taking immunosuppressive medications.


COVID-19 vaccines are safe and effective. COVID-19 vaccines were evaluated in tens of thousands of participants in clinical trials. The vaccines met the Food and Drug Administration’s (FDA) rigorous scientific standards for safety, effectiveness, and manufacturing quality needed to support emergency use authorization (EUA). Millions of people in the United States have received COVID-19 vaccines since they were authorized for emergency use by FDA. These vaccines have undergone and will continue to undergo the most intensive safety monitoring in U.S. history.

Key Things to Know About the COVID Vaccines:

  • COVID-19 vaccines are safe and effective.
  • Side effects are normal signs your body is building protection and usually go away in a few days.  
  • Available to every person 6 months of age and older.
  • Free of charge, whether you have health insurance or not.
  • Available regardless of immigration status.

What to Expect After Vaccination

  • You may have arm soreness and feel achy.
  • Some people have a headache and/or fever.


New research shows that although it’s safe, individuals who are immunocompromised, have had a solid organ transplant, or are on immunosuppressive medications may produce little to no antibody response to the current mRNA vaccines. This means that despite vaccination, there may be a significant proportion of the population that is not protected from SARS-CoV-2 infection at the level described in the clinical trials.


The Centers for Disease Control and Prevention recommends the following:

2 Boosters

  • People 65 years and older, 50–64 years with underlying medical conditions, or 18 years and older who live in long-term care settings should receive a booster shot.
  • Adults ages 50 years and older
  • Some people ages 12 years and older who are moderately or severely immunocompromised

1 Booster

We will get through this together!

The E.WE Foundation in partnership with Greater Than COVID is sharing facts about the COVID-19 vaccine.

Source: Greater Than COVID | Centers for Disease Control and Prevention